Neuronoff Grants

$1.73M DOD SCIRP - Translational grant on TibN tibialis clinical RCT for neurogenic bladder (partnership with UT Health, 3y '25-'28)
This grant funds a clinical randomized controlled trial evaluating the Injectrode for treating neurogenic bladder in spinal cord injury (SCI) patients. The study will assess the safety and efficacy of the device when implanted along the tibial nerve, with the goal of reducing medication dependence and improving quality of life for individuals with SCI.

$3.2M NIH R01 - "An Injectable Electrode to Better Isolate the Posterior Tibial Nerve to Treat OAB" (2024; 5y; 1R01NS138422-01, in partnership with UWisc and CWRU)
This five-year grant supports the development of an innovative injection tool with embedded fiber optic visualization capabilities, optimizing minimally invasive electrode placement for posterior tibial nerve stimulation in overactive bladder treatment. The research aims to revolutionize how neuromodulation procedures are performed, utilizing the minimally invasive nature of the Injectrode.

$2.2M NIH HEAL - "The Injectrode - A Truly Injectable Electrode for Dorsal Root Ganglion Stimulation to Treat Pain" (2019; 1U18EB029251-01, in partnership with UWisc, CWRU, UMich, and UPenn)
Part of the NIH HEAL Initiative to address the opioid crisis, this grant supports the development of the Injectrode as a minimally invasive alternative to conventional pain management. The research focuses on dorsal root ganglion stimulation for treating chronic pain without opioids.

$315K NIH HEAL Supplement - To use injectrode to clear misfolded proteins for Alzheimer's (2021; 3U18EB029251-01S1)
This supplementary grant extends the Injectrode technology to address neurodegenerative diseases. The research explores using the device to stimulate cranial nerves to clear misfolded proteins associated with Parkinson's and Alzheimer's diseases, potentially preventing symptom progression at early disease stages.

$600K NIH SBIR - "The Injectrode- An injectable, easily removable electrode as a trial lead for baroreceptor activation therapy to treat hypertension and heart failure" (2023; 1R43HL169127-01)
This Small Business Innovation Research grant focuses on adapting the Injectrode for cardiovascular applications. The research explores using the technology for carotid sinus nerve stimulation to treat hypertension and heart failure through baroreceptor activation therapy.

$500K Ohio Third Frontier Research Incentive - "Injectable multi-level sacral root neuromodulation interface for the treatment of SCI bladder dysfunction" (2021; 1R43HL169127-01)
This state-funded research incentive supports the development of a multi-level sacral root neuromodulation system using the Injectrode technology to address bladder dysfunction in spinal cord injury patients, offering a minimally invasive alternative to conventional surgical approaches.

$300K IQT In-Q-Tel EEI - "Embedded Entrepreneur Initiative" (2020)
This initiative provided funding and strategic support to accelerate the commercialization of Neuronoff's technology. The program helped innovative companies bridge the gap between research and market-ready products through entrepreneurial expertise and resources.

$250K DARPA Seedling - (2017; DARPA Seedling Subaward UW#MSN239801)
As part of the DARPA Targeted neuroplasticity Program (TNT), the Injectrode was evaluated as a minimally invasive neuromodulation technology to stimulate and/or selectively block small fibers in preclinical studies.